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Publications

欧文原著 (* corresponding author)

  1. Park, G., Shin, M., Lee, W. Hotta, A., Kobayashi, T. and *Kosodo, Y.
    Direct visualization of the transition status during neural differentiation by dual-fluorescent reporter
    human pluripotent stem cells.    
    Stem Cell Reports. 17, 1903-1913 (2022)

  2. Kaise, T., Fukui, M., Sueda, R., Piao, W., Yamada, M., Kobayashi, T., Imayoshi, I. and *Kageyama, R. 
    Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity.
    Genes Dev. 36, 23-37 (2022) 

  3. Zhang, J., Uchiyama, J., Imami, K., Ishihama, Y., Kageyama, R. and *Kobayashi, T.            Novel roles of small extracellular vesicles in regulating the quiescence and proliferation of neural stem cells. Front. Cell. Dev. Biol. 9, 762293 (2021)

  4. *Kobayashi, T., Piao, W., Takamura, T., Kori, H., Miyachi, H., Kitano, S., Iwamoto, Y., Yamada, M., Imayoshi, I., Shioda, S., Ballabio, A., and *Kageyama, R.                           Enhanced lysosomal degradation maintains the quiescent state of neural stem cells.        Nat. Commun. 10, 5446. (2019)

  5. Komori, H., Golden, K. L., Kobayashi, T., Kageyama, R., and *Lee, C.-Y.                  Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors during Drosophila asymmetric neural stem cell division.                          Genes Dev. 32, 1–12. (2018)

  6. *Kobayashi, T., Iwamoto, Y., Takashima, K, Isomura, A., Kosodo, Y., Kawakami, K., Nishioka, T.,Kaibuchi, K., and *Kageyama, R.                                     Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation.             FEBS J. 282, 2475-2487. (2015)

  7. Nagashima, F., Suzuki, I. K., Shitamukai, A., Sakaguchi, H., Iwashita, M., Kobayashi, T., Tone, S., Toida, K., Vanderhaeghen, P. and *Kosodo, Y.                                 Novel and robust transplantation reveals the acquisition of polarized processes by cortical cells derived from mouse and human pluripotent stem cells.                           Stem Cells Dev. 23, 2129-2142. (2014)

  8. Ueo, T., Imayoshi, I., Kobayashi, T., Ohtsuka, T., Seno, H., Nakase, H., Chiba, T. and *Kageyama, R.       The role of Hes genes in intestinal development, homeostasis and tumor formation.      Development. 139, 1071-1082. (2012)                         

  9. *Kobayashi, T. and *Kageyama, R.                                                                                                                         Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling.        Genes Cells. 15, 689-698. (2010)                                 

  10. *Kobayashi, T., Mizuno, H., Imayoshi, I., Furusawa, C., Shirahige, K. and *Kageyama, R.                                      The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells.     Genes & Development. 23, 1870-1875. (2009)

  11. Ishii, A., Kobayashi, T. and *Kageyama, R. Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7.                                                                                                                Biochem Biophys Res Commun. 372, 142-6. (2008) 

  12. Kobayashi, T., Manno, A. and *Kakizuka, A.                                                                                                Involvement of valosin-containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates.                                                                                                                                              Genes Cells. 12, 889-901. (2007)

  13. Kobayashi, T., Tanaka, K., Inoue, K. and *Kakizuka, A.                                                                                  Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.                                                     J. Biol. Chem. 277, 47358-65. (2002)

  14. Kobayashi, T., Takahashi, Y. and *Ito, K.                                                                                                      Identification of a segment of DsbB essential for its respiration-coupled oxidation.                         Molecular Microbiology 39, 158-165. (2001)

  15. Kobayashi, T. and *Ito, K.                                                                                                                              Respiratory chain strongly oxidizes the CXXC motif of DsbB in the Escherichia coli dislfide bond formation pathway.                                                                                                                                                    The EMBO Journal. 18, 1192-1198. (1999)

  16. Kobayashi, T., Kishigami, S., Sone, M., Inokuchi, H., Mogi, T. and *Ito, K.                                                     Respiratory chain is required to maintain oxidized states of DsbA-DsbB disulfide bond formation system in aerobically growing Escherichia coli cells.                                                                                            Proc. Natl. Acad. Sci. USA 94, 11857-11862. (1997)

欧文総説 (* corresponding author)

  1. *Kobayashi, T. and *Kageyama, R.                                  Lysosomes and signaling pathways for maintenance of quiescence in adult neural stem cells.      FEBS J. (2020) https://doi.org/10.1111/febs.15555

  2. *Kobayashi, T. and *Kageyama, R.                                    Expression dynamics and functions of Hes genes in development and diseases.            Curr Top Dev Biol. 110, 263-283. (2014)

  3. Harima, Y., Imayoshi, I., Shimojo, H., Kobayashi, T., and Kageyama, R.                   The roles and mechanism of ultradian oscillatory expression of the mouse Hes genes.       Semin Cell Dev Biol. 34, 85-90. (2014)

  4. *Kobayashi, T. and Kageyama, R.                                   Hes1 oscillations contribute to heterogeneous differentiation responses in embryonic stem cells.   Genes. 2, 219-228 (2011)

  5. *Kageyama, R., Niwa, Y., Shimojo, H., Kobayashi, T., Ohtsuka, T.                    Ultradian oscillations in Notch signaling regulate dynamic biological events.             Curr. Top. Dev. Biol. 92, 311-331. (2010)

  6. *Kobayashi, T. and Kageyama, R.                                   Hes1 oscillation: making variable choices for stem cell differentiation.                 Cell Cycle. 9, 207-8. (2010)

  7. *Kobayashi, T. and Kageyama, R.                                                                                                                        Dynamic advances in NF-kappaB signaling analysis.                                                                                              Sci Signal. 2, pe47. (2009)

  8. *Kageyama, R., Ohtsuka, T. and Kobayashi, T.                                                                                                    Roles of Hes genes in neural development.                                                                                                        Dev Growth Differ. 50 Suppl 1, S97-103. (2008)

  9. *Kageyama, R., Ohtsuka, T. and Kobayashi, T.                                                                                                       The Hes gene family: repressors and oscillators that orchestrate embryogenesis.                           Development. 134, 1243-51. (2007)

  10. Kobayashi, T. and *Kakizuka, A.                                                                                                                            Molecular analyses of Machado-Joseph disease.                                                                                          Cytogenet Genome Res. 100, 261-75. (2003)

和文総説

  1. *小林妙子  神経幹細胞におけるリソソーム機能 実験医学 41(11), 1743-1747. (2023)

  2. *小林妙子(ゲストエディター)特集「リソソーム研究の新展開「特集によせて」生体の科学73巻3号, 190.(2022)

  3. *小林妙子
    「成体神経幹細胞の休眠を制御しているリソソーム

  4. *小林妙子「Hesファミリー」脳科学辞典(2013) DOI:10.14931/bsd.1880 生体の科学73巻3号, 196−201.(2022)

  5. *小林妙子、影山龍一郎「幹細胞分化の運命決定に寄与するリズム現象」医学のあゆみ 235, 953-954. (2010)

  6. *影山龍一郎、小林妙子「bHLH 因子 Hes1 による神経分化制御」蛋白質 核酸 酵素 53, 318-3239. (2008)

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